What to watch for: The Patriots have relied on the run game in recent weeks, averaging 137.4 yards over their past five games and helping take some pressure off rookie quarterback Mac Jones. (Game times are Sunday unless otherwise noted.) It all culminates with a Monday Night Football matchup between the Rams and the 49ers on ESPN. Let's get into the full Week 10 slate, including a red-hot Titans defense facing the Saints, Chase Young chasing after Tom Brady, the returns of Russell Wilson and Aaron Rodgers and a big AFC West matchup between the Chiefs and Raiders on Sunday night. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football. ESPN researcher Kyle Soppe hands out helpful fantasy football tips as well. Our NFL Nation reporters bring us the biggest keys to every game, a bold prediction for each matchup and, of course, final score picks.Īdditionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. The Week 10 NFL schedule for the 2021 season is stacked with great matchups, and we've got you covered with what you need to know heading into the weekend. NFL Week 10 game picks, schedule guide, fantasy football tips, odds, injuries and more

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